EVENT

SYNOPSIS

It is with great pleasure that we invite you to attend “Deciphering the function of intrinsically disordered protein regions: new horizons’ – an interactive, online webinar that will take place (via Zoom) on Friday 4th June, 14.00-17.00 GMT. A series of short pre-recorded talks will be available from Thursday 3rd June for registered attendees to view before the meeting.

Given the majority of cellular processes are controlled by protein-protein interactions (PPIs), the science of understanding and manipulating PPIs, plays an important role in fathoming the biology of healthy and diseased states. While many proteins adopt a regular 3D shape, it is now accepted that large sections of many proteins termed intrinsically disordered regions (IDRs) have no fixed shape. To truly understand the “molecular rules of life”, it is necessary to understand how the structures of these “shape-shifters” changes with time, how this influences their PPIs, how this impacts on the life-cycle of healthy/unhealthy cells, and ultimately how to control these properties using chemistry. Within the last decade, enormous progress has been made in characterizing PPIs involving IDRs, and the field continues to generate intense scientific interest in academia and industry. However, understanding how the dynamics of IDRs affect networks of PPIs that regulate functionally important cellular processes and targeting IDRs remain unsolved. Achieving this goal will lead to new probes to study cell signalling pathways, and drug discovery programmes addressing unmet medical needs.

This meeting will celebrate the progress made, new approaches and future challenges in IDR research. It is being held to coincide with the beginning of Structures and Probes of Intrinsically Disordered Regions (SPIDR), a major UKRI-BBRSC investment that will develop and use a state-of-the-art, integrated chemical and biological toolkit to understand and manipulate interactions of IDRs with the Aurora-A kinase in vitro and in cells.

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FORMAT

This meeting will take place online (via Zoom) on Friday 4th June, 14.00-17.00 GMT. A series of pre-recorded talks will be available from Thursday 3rd June for registered attendees to view before the meeting.

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ATTENDEES

The event is aimed at all scientists including PhD students, from industry and academia, with an interest in the understanding and manipulating protein-protein interactions involving intrinsically disordered regions. This includes medicinal and computational chemists, structural biologists, biochemists, chemical biologists, and molecular and cell biologists

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PROGRAMME

Thursday 3rd June

Three pre-recorded 20-minute talks will be made available for registered attendees to view from Thursday 3rd June.

Friday 4th June

14.00-17.00 GMT

An afternoon of live, interactive talks (via Zoom)

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CONFIRMED SPEAKERS

Professor Richard Bayliss, University of Leeds

Professor Erica Golemis, Fox Chase Cancer Centre

Professor Ben Schuler, University of Zurich

Dr Sarah Shammas, University of Oxford

Professor Andy Wilson, University of Leeds

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BOOKING PROCESS/DEADLINES

This event is free to attend, however, places are limited so register early to avoid disappointment.

Registration is via Zoom following this link:

https://universityofleeds.zoom.us/meeting/register/tZ0ldu-rpjksEtHFpV8my3atZY-piKdgcKhS

Please note that all registrations are subject to availability. You will receive a confirmation email once your booking has been reviewed by the host. We aim to respond to your registration request promptly:

If you have not received a confirmation email within two working days please contact poppi@leeds.ac.uk. Please note the PoPPI office is closed at the weekends.

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ORGANISING COMMITTEE

· Professor Andrew Wilson, University of Leeds

· Amy Rees, University of Leeds

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SCIENTIFIC COMMITTEE

· Professor Richard Bayliss, University of Leeds

· Dr Fanni Gergely, University of Oxford

· Professor Colin Johnson, University of Leeds

· Dr Takashi Ochi, University of Leeds

· Professor Sheena Radford OBE, FMedSci, FRS, University of Leeds

· Dr Darren Tomlinson, University of Leeds

· Dr Megan Wright, University of Leeds

· Professor Andrew Wilson, University of Leeds

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CONTACT TEAM

For further information, please email poppi@leeds.ac.uk