SPIDR Outputs

Aubrey, L., Ninkina, N., Ulamec, S., Abramycheva, N., Vasili, E., Devine, O. …Radford, S. (2024) Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid. PNAS 121 (2) e2309700120.

Carden, S., Vitiello, E., Rosa e Silva, I., Holder, J., Quarantotti, V., Kishore, K., Roamio Franklin, V.N., D’Santos, C., Ochi, T., van Breugel, M. & Gergely, F. (2023) Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method. Dev. Cell 58 (21) 2393-2410.e9.

Dawber, R., Gimenez, D., Batchelor, M., Miles, J.A., Wright, M.H., Bayliss, R., A.J. (2023) Inhibition of Aurora A/N-Myc protein-protein interaction using peptidomimetics: Understanding the role of peptide cyclization. ChemBioChem e202300649.

Zhang, P., Walko, M., Wilson, A.J., (2023) Maleimide constrained BAD BH3 domain peptides as BCL-xL Inhibitors: A Versatile Approach to Rapidly Identify Sites Compatible with Peptide Constraining. Bioorg. Med. Chem. Lett., 87, 129260.

Arter, C., Trask, L., Ward, S., Yeoh, S., Bayliss, R (2022) Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors. J Biol Chem. 298(8) DOI: 10.1016/j.jbc.2022.102247

Zhang, P., Walko, M., & Wilson, A.J., (2023) Rational Design of Harakiri (HRK)-Derived Constrained Peptides as BCL-xL inhibitors. Chem. Commun., DOI: 10.1039/D2CC06029A

Batchelor, M., Dawber, R.S., Wilson, A.J., & Bayliss, R. (2022) α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motif. Biochem J, 479 (5), 687–700