SPIDR Outputs

Gimenez, D., Walko, M., Miles, J.A.,  Bayliss, R., Wright, M.H. & Wilson, A.J. (2024) Constrained TACC3 peptidomimetics for a non-canonical protein-protein interface elucidate allosteric communication in Aurora-A Kinase, ChemRxiv, 10.26434/chemrxiv-2024-299w9.

Li, Y., Trinh, C.H., Warriner, S.L., & Wilson, A.J. (2024) Biophysical and Structural Analyses of the Interaction between the SHANK1 PDZ Domain and an Internal SLiM, Biochem. J. BCJ20240126.

Cawood, E.E., Baker, E.,  Edwards, T.A., Woolfson, D.N., Karamanos, T.K., & Wilson, A.J (2024) Peptidomimetic inhibitors of β-strand-mediated protein-protein interactions: tuning binding affinity of intrinsically disordered sequences through backbone modification. Chem. Sci. DOI: 10.1039/D4SC02240H.

Smith, F.R., Meehan, D., Griffiths, R.C., Knowles, H.J., Zhang, P, Williams, H.L., Wilson, A.J. & Mitchell, N.J. (2024) Peptide macrocyclisation via intramolecular interception of visible-light-mediated desulfurisation, Chem. Sci. 2024, DOI: 10.1039/D3SC05865D.

Aubrey, L., Ninkina, N., Ulamec, S., Abramycheva, N., Vasili, E., Devine, O. …Radford, S. (2024) Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid. PNAS 121 (2) e2309700120.

Smith, F., Meehan, D., Knowles, H., Zhang, P., Williams, H., Wilson, A.J. & Mitchell, N. (20024) Peptide Macrocyclization via Intramolecular Interception of Visible-Light-Mediated Desulfurization. ChemRxiv

Carden, S., Vitiello, E., Rosa e Silva, I., Holder, J., Quarantotti, V., Kishore, K., Roamio Franklin, V.N., D’Santos, C., Ochi, T., van Breugel, M. & Gergely, F. (2023) Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method. Dev. Cell 58 (21) 2393-2410.e9.

Cawood, E., Baker, E., Edwards, T., Woolfson, D., Karamanos, T. & Wilson, A.J. (2023) Understanding β-strand mediated protein-protein interactions using peptidomimetics: tuning binding affinity of intrinsically disordered sequences by covalent backbone modification. ChemRxiv.

Khan, H. & Ochi, T. (2023) Plant PAXX has an XLF-like function and stimulates DNA end joining by the Ku-DNA ligase IV/XRCC4 complex.  TPJ. 116 (1)1-321.

Dawber, R., Gimenez, D., Batchelor, M., Miles, J.A., Wright, M.H., Bayliss, R., A.J. (2023) Inhibition of Aurora A/N-Myc protein-protein interaction using peptidomimetics: Understanding the role of peptide cyclization. ChemBioChem e202300649.

Zhang, P., Walko, M., Wilson, A.J., (2023) Maleimide constrained BAD BH3 domain peptides as BCL-xL Inhibitors: A Versatile Approach to Rapidly Identify Sites Compatible with Peptide Constraining. Bioorg. Med. Chem. Lett., 87, 129260.

Arter, C., Trask, L., Ward, S., Yeoh, S., Bayliss, R (2022) Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors. J Biol Chem. 298(8) DOI: 10.1016/j.jbc.2022.102247

Zhang, P., Walko, M., & Wilson, A.J., (2023) Rational Design of Harakiri (HRK)-Derived Constrained Peptides as BCL-xL inhibitors. Chem. Commun., DOI: 10.1039/D2CC06029A

Batchelor, M., Dawber, R.S., Wilson, A.J., & Bayliss, R. (2022) α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motif. Biochem J, 479 (5), 687–700