SPIDR Outputs

Gimenez, D., Walko, M., Miles, J.A.,  Bayliss, R., Wright, M.H. & Wilson, A.J. (2025) Constrained TACC3 peptidomimetics for a non-canonical protein-protein interface elucidate allosteric communication in Aurora-A Kinase, Chem. Sci. , 16, 354-363.

Holder, J., Miles, J.A., Batchelor, M., Popple, H., Walko, M., Yeung, W., Kannan, N., Wilson, A.J., Bayliss, R., & Gergely, F. (2024) CEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2, EMBO J.,  43, 5381-5420.

Schiffrin, B., Crossley, J.A., Walko, M., Machin, J.M., Khan, G.N., Manfield, I.W., Wilson, A.J., Brockwell, D.J., Fessl, T., Calabrese, A.N., Radford, S.E. & Zhuravleva, A. (2024) Dual client binding sites in the ATP-independent chaperone SurA, Nature Commun., 15, 8071.

Gimenez, D., Walko, M., Miles, J.A.,  Bayliss, R., Wright, M.H. & Wilson, A.J. (2024) Constrained TACC3 peptidomimetics for a non-canonical protein-protein interface elucidate allosteric communication in Aurora-A Kinase, ChemRxiv, 10.26434/chemrxiv-2024-299w9.

Li, Y., Trinh, C.H., Warriner, S.L., & Wilson, A.J. (2024) Biophysical and Structural Analyses of the Interaction between the SHANK1 PDZ Domain and an Internal SLiM, Biochem. J. 481, 945-955.

Cawood, E.E., Baker, E.,  Edwards, T.A., Woolfson, D.N., Karamanos, T.K., & Wilson, A.J (2024) Peptidomimetic inhibitors of β-strand-mediated protein-protein interactions: tuning binding affinity of intrinsically disordered sequences through backbone modification. Chem. Sci. 15, 10237-10245.

Smith, F.R., Meehan, D., Griffiths, R.C., Knowles, H.J., Zhang, P, Williams, H.L., Wilson, A.J. & Mitchell, N.J. (2024) Peptide macrocyclisation via intramolecular interception of visible-light-mediated desulfurisation, Chem. Sci., 15, 10237-10245.

Aubrey, L., Ninkina, N., Ulamec, S., Abramycheva, N., Vasili, E., Devine, O. …Radford, S. (2024) Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid. Proc. Nat. Acad. Sci. USA, 121, e2309700120.

Smith, F., Meehan, D., Knowles, H., Zhang, P., Williams, H., Wilson, A.J. & Mitchell, N. (2024) Peptide Macrocyclization via Intramolecular Interception of Visible-Light-Mediated Desulfurization. ChemRxiv, 10.26434/chemrxiv-2023-865v6-v3

Dawber, R., Gimenez, D., Batchelor, M., Miles, J.A., Wright, M.H., Bayliss, R., A.J. (2024) Inhibition of Aurora A/N-Myc protein-protein interaction using peptidomimetics: Understanding the role of peptide cyclization. ChemBioChem, 25, e202300649.

Carden, S., Vitiello, E., Rosa e Silva, I., Holder, J., Quarantotti, V., Kishore, K., Roamio Franklin, V.N., D’Santos, C., Ochi, T., van Breugel, M. & Gergely, F. (2023) Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method. Dev. Cell, 58, 2393-2410.e9.

Cawood, E., Baker, E., Edwards, T., Woolfson, D., Karamanos, T. & Wilson, A.J. (2023) Understanding β-strand mediated protein-protein interactions using peptidomimetics: tuning binding affinity of intrinsically disordered sequences by covalent backbone modification. ChemRxiv. 10.26434/chemrxiv-2023-xglb4-v3

Khan, H. & Ochi, T. (2023) Plant PAXX has an XLF-like function and stimulates DNA end joining by the Ku-DNA ligase IV/XRCC4 complex.  TPJ. 116 (1)1-321.

Zhang, P., Walko, M., Wilson, A.J., (2023) Maleimide constrained BAD BH3 domain peptides as BCL-xL Inhibitors: A Versatile Approach to Rapidly Identify Sites Compatible with Peptide Constraining. Bioorg. Med. Chem. Lett., 87, 129260.

Zhang, P., Walko, M., & Wilson, A.J., (2023) Rational Design of Harakiri (HRK)-Derived Constrained Peptides as BCL-xL inhibitors. Chem. Commun., 59, 1697-1700.

Arter, C., Trask, L., Ward, S., Yeoh, S., Bayliss, R (2022) Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors. J Biol Chem., 298, 102247

Batchelor, M., Dawber, R.S., Wilson, A.J., & Bayliss, R. (2022) α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motif. Biochem J, 479, 687–700