Structures and Probes of Intrinsically Disordered Regions meeting – 10 June 2024

Join us at The University of Leeds on 10th June for a one-day, interdisciplinary meeting organized by the SPiDR project team on intrinsically disordered regions (IDRs). 

The roles of many proteins rely heavily on IDRs. These are protein regions without obvious specific structural features that are, surprisingly, found and conserved across biology and evolution. 

The meeting is open to everyone and aims to bring together researchers across disciplines to discuss the biological role of IDRs in health and disease and the physiochemical properties that make them integral to these processes. 


Who should attend?

Everyone enthusiastic about IDRs. Particularly, encouraging early-career scientists including postgraduate students and postdoctoral researchers using biochemistry and biophysics, chemical biology, structural biology and cell biology.


Speakers

We are excited to confirm speakers Prof. Peter Tompa (VIB-VUB Center for Structural Biology), Dr Sarah Shammas (University of Oxford), and Dr Markus Schade (AstraZeneca).

Prof. Peter Tompa (VIB-VUB Center for Structural Biology)

Dr Sarah Shammas (University of Oxford)

Dr Markus Schade (AstraZeneca)

In addition, this meeting will provide an opportunity for early career researchers (incl. Postdoctoral researchers and PhD candidates) to give short oral presentations or participate in a poster session. 


Programme  

The meeting is taking place at The School of Chemistry, University of Leeds

Time Location
11:00-11:30RegistrationChaston Chapman Lounge
11.30-11.40Welcome (Dr Takashi Ochi, University of Leeds)Lecture Theatre B
11:40-12:25Keynote: Dr Sarah Shammas (University of Oxford) “The transition state for coupled folding and binding of a disordered DNA binding domain resembles the unbound state”Lecture Theatre B
12:25-12:45Dr Arnout Kalverda (University of Leeds) “Order in disorder: AUX/IAA protein and its TIR1-Aux/IAA auxin co-receptor system”Lecture Theatre B
12:45-13:05Dr Ikhlas Ahmed (University of Strathclyde) Ion mobility mass spectrometry unveils conformational effects of drug lead EPI-001 on the intrinsically disordered N-terminal domain of the Androgen ReceptorLecture Theatre B
13.05-14:00  Sandwich LunchChaston Chapman Lounge
Poster SessionChaston Chapman Lounge
14:00-14:45Industry talk: Dr Markus Schade (AstraZeneca) “Hit finding for IDR targets in Industry”Lecture Theatre B
14:45-15:05Dr Eoin Leen (University of Leeds) “N-myc recruits the general transcription factor TFIIIC via the DNA binding surface of TFIIIC5”Lecture Theatre B
15:05-15:25Dr Xiaohan Li (University of Dundee) “Intrinsically disordered regions in Sec24 paralogs tune COPII vesicle size and occupancy”Lecture Theatre B
15:25-15:45Dr Emily Byrd (University of Leeds) Understanding how ALS-associated mutations alter the structure and phase separation propensity of the TDP-43 C-terminal domain using structural mass spectrometryLecture Theatre B
15:45-16:00Coffee breakChaston Chapman Lounge
16:00-17:00Keynote: Prof Peter Tompa (VIB-VUB Center for Structural Biology) “Repeat-driven biomolecular condensation in health and disease”Lecture Theatre B
17:00Close 

Registration

Registration is now open and is £25. Please book your slot through our online store. A sandwich lunch and refreshments are included.

Cancellations can be made up to 30 days before the meeting for a full refund. No refunds will be made within 30 days of the event. Please contact Amy Rees (a.l.rees@leeds.ac.uk) if you require a refund.

Registration **extended to Friday 17 May, 17:00 (UK time)**


Call for Abstracts

The meeting organizers are pleased to invite you to submit an abstract by Friday 17 May, 17:00, 2024 for consideration for Early Career Researcher Meeting: Structures and Probes of Intrinsically Disordered Regions. Please adhere to the guidance in the template and email to Amy Rees (a.l.rees@leeds.ac.uk)

Deadline for abstracts **extended to Friday 17 May, 17:00 (UK time)**


 Organising Committee

  • Dr Takashi Ochi, University of Leeds
  • Dr Martin Walko, University of Leeds
  • Dr Matthew Batchelor, University of Leeds
  • Dr James Holder, University of Oxford
  • Dr Jennifer Miles, University of Leeds
  • Dr Diana Gimenez-Ibanex, University of Leeds
  • Amy Rees, University of Leeds

Contact:

Ms Amy Rees, University of Leeds (a.l.rees@leeds.ac.uk)